解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Aligning protein-protein interaction (PPI) networks is very important to discover the functionally conserved sub-structures between different species. In recent years, the global PPI network alignment problem has been extensively studied aiming at finding the one-to-one alignment with the maximum matching sc...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5027-9
更新日期:2018-09-24 00:00:00
abstract:BACKGROUND:The plastid acquisition by secondary endosymbiosis is a driving force for the algal evolution, and the comparative genomics was required to examine the genomic change of symbiont. Therefore, we established a pipeline of a de novo assembly of middle-sized genomes at a low cost and with high quality using long...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5067-1
更新日期:2018-09-24 00:00:00
abstract:BACKGROUND:Although hatching is perhaps the most abrupt and profound metabolic challenge that a chicken must undergo; there have been no attempts to functionally map the metabolic pathways induced in liver during the embryo-to-hatchling transition. Furthermore, we know very little about the metabolic and regulatory fac...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5080-4
更新日期:2018-09-21 00:00:00
abstract:BACKGROUND:JWB phytoplasma is a kind of insect-transmitted and uncultivable bacterial plant pathogen causeing a destructive Jujube disease. To date, no genome information about JWB phytoplasma has been published, which hindered its characterization at genomic level. To understand its pathogenicity and ecology, the geno...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5075-1
更新日期:2018-09-19 00:00:00
abstract:BACKGROUND:Acquisition of external phosphorus (P) and optimisation of internal P are essential for plant growth and development, and insufficient availability of P in soils is a major challenge in agriculture. Members of the purple acid phosphatase (PAP) family of enzymes are candidates for increasing P use efficiency....
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5022-1
更新日期:2018-08-31 00:00:00
abstract:BACKGROUND:Mitochondria are organelles that fulfill a fundamental role in cell bioenergetics, as well as in other processes like cell signaling and death. Small non-coding RNAs (sncRNA) are now being considered as pivotal post-transcriptional regulators, widening the landscape of their diversity and functions. In mamma...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5020-3
更新日期:2018-08-28 00:00:00
abstract:BACKGROUND:Mitochondrial genomes of flowering plants (angiosperms) are highly dynamic in genome structure. The mitogenome of the earliest angiosperm Amborella is remarkable in carrying rampant foreign DNAs, in contrast to Liriodendron, the other only known early angiosperm mitogenome that is described as 'fossilized'. ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4991-4
更新日期:2018-08-14 00:00:00
abstract:BACKGROUND:Maintaining maximum genetic diversity and preserving breed viability in conserved populations necessitates the rigorous evaluation of conservation schemes. Three chicken breeds (Baier Yellow Chicken (BEC), Beijing You Chicken (BYC) and Langshan Chicken (LSC)) are currently in conservation programs in China. ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4973-6
更新日期:2018-08-09 00:00:00
abstract::The reporting of the first draft of the human genome in 2000 brought with it much hope for the future in what was felt as a paradigm shift toward improved health outcomes. Indeed, we have now mapped the majority of variation across human populations with landmark projects such as 1000 Genomes; in cancer, we have catal...
journal_title:BMC genomics
pub_type: 杂志文章,评审
doi:10.1186/s12864-018-4963-8
更新日期:2018-08-08 00:00:00
abstract:BACKGROUND:Since 2007, bacterial canker caused by Pseudomonas syringae pv. actinidiae (Psa) has become a pandemic disease leading to important economic losses in every country where kiwifruit is widely cultivated. Options for controlling this disease are very limited and rely primarily on the use of bactericidal compou...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4967-4
更新日期:2018-08-06 00:00:00
abstract:BACKGROUND:Bacteria belonging to the Rhodococcus genus play an important role in the degradation of many contaminants, including methylbenzenes. These bacteria, widely distributed in the environment, are known to be a powerhouse of numerous degradation functions, due to their ability to metabolize a wide range of organ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4965-6
更新日期:2018-08-06 00:00:00
abstract:BACKGROUND:Meloidogyne incognita is a devastating nematode that causes significant losses in cucumber production worldwide. Although numerous studies have emphasized on the susceptible response of plants after nematode infection, the exact regulation mechanism of M. incognita-resistance in cucumber remains elusive. Ver...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4979-0
更新日期:2018-08-03 00:00:00
abstract:BACKGROUND:RNA-seq and small RNA-seq are powerful, quantitative tools to study gene regulation and function. Common high-throughput sequencing methods rely on polymerase chain reaction (PCR) to expand the starting material, but not every molecule amplifies equally, causing some to be overrepresented. Unique molecular i...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4933-1
更新日期:2018-07-13 00:00:00
abstract:BACKGROUND:Bacterial invasive infection and host immune response is fundamental to the understanding of pathogen pathogenesis and the discovery of effective therapeutic drugs. However, there are very few experimental studies on the signaling cross-talks between bacteria and human host to date. METHODS:In this work, ta...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4873-9
更新日期:2018-06-28 00:00:00
abstract:BACKGROUND:Arrhythmogenic cardiomyopathy (ACM) is a genetic autosomal disease characterized by abnormal cell-cell adhesion, cardiomyocyte death, progressive fibro-adipose replacement of the myocardium, arrhythmias and sudden death. Several different cell types contribute to the pathogenesis of ACM, including, as recent...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4876-6
更新日期:2018-06-25 00:00:00
abstract:BACKGROUND:Animals are thought to achieve lignocellulose digestion via symbiotic associations with gut microbes; this view leads to significant focus on bacteria and fungi for lignocellulolytic systems. The presence of biomass conversion systems hardwired into animal genomes has not yet been unequivocally demonstrated....
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4861-0
更新日期:2018-06-20 00:00:00
abstract:BACKGROUND:Sugarcane (Saccharum L. plant) is an important crop for sugar and bio-energy production around the world. Among sugarcane diseases, smut caused by Sporisorium scitamineum is one of the major fungal diseases causing severe losses to the sugarcane industry. The use of PCR reference genes is essential to the no...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4854-z
更新日期:2018-06-19 00:00:00
abstract:BACKGROUND:Cottonseed is one of the most important raw materials for plant protein, oil and alternative biofuel for diesel engines. Understanding the complex genetic basis of cottonseed traits is requisite for achieving efficient genetic improvement of the traits. However, it is not yet clear about their genetic archit...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4837-0
更新日期:2018-06-13 00:00:00
abstract:BACKGROUND:Nitrogen (N) is a key macronutrient required for plant growth and development. In this study, watermelon plants were grown under hydroponic conditions at 0.2 mM N, 4.5 mM N, and 9 mM N for 14 days. RESULTS:Dry weight and photosynthetic assimilation at low N (0.2 mM) was reduced by 29 and 74% compared with h...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4856-x
更新日期:2018-06-13 00:00:00
abstract:BACKGROUND:Due to the advancement in high throughput technology, single nucleotide polymorphism (SNP) is routinely being incorporated along with phenotypic information into genetic evaluation. However, this approach often cannot achieve high accuracy for some complex traits. It is possible that SNP markers are not suff...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4787-6
更新日期:2018-06-05 00:00:00
abstract:BACKGROUND:Congenital heart disease (CHD) is the leading non-infectious cause of death in infants. Monozygotic (MZ) twins share nearly all of their genetic variants before and after birth. Nevertheless, MZ twins are sometimes discordant for common complex diseases. The goal of this study is to identify genomic and epig...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4814-7
更新日期:2018-06-04 00:00:00
abstract:BACKGROUND:Parasitoid wasps are well-known natural enemies of major agricultural pests and arthropod borne diseases. The parasitoid wasp Macrocentrus cingulum (Hymenoptera: Braconidae) has been widely used to control the notorious insect pests Ostrinia furnacalis (Asian Corn Borer) and O. nubilalis (European corn borer...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4783-x
更新日期:2018-05-30 00:00:00
abstract:BACKGROUND:Chloroplasts have their own genomes, independent from nuclear genomes, that play vital roles in growth, which is a major targeted trait for genetic improvement in Populus. Angiosperm chloroplast genomes are maternally inherited, but the chloroplast' variation pattern of poplar at the single-base level during...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4813-8
更新日期:2018-05-29 00:00:00
abstract:BACKGROUND:The monophyly of flatfishes has not been supported in many molecular phylogenetic studies. The monophyly of Pleuronectoidei, which comprises all but one family of flatfishes, is broadly supported. However, the Psettodoidei, comprising the single family Psettodidae, is often found to be most closely related t...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4788-5
更新日期:2018-05-25 00:00:00
abstract:BACKGROUND:The emergence of epithelia was the foundation of metazoan expansion. Epithelial tissues are a hallmark of metazoans deeply rooted in the evolution of their complex developmental morphogenesis processes. However, studies on the epithelial features of non-bilaterians are still sparse and it remains unclear whe...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4715-9
更新日期:2018-05-24 00:00:00
abstract:BACKGROUND:Small RNA (sRNA) sequences are known to have a broad impact on gene regulation by various mechanisms. Their performance for the prediction of hybrid traits has not yet been analyzed. Our objective was to analyze the relation of parental sRNA expression with the performance of their hybrids, to develop a sRNA...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4708-8
更新日期:2018-05-21 00:00:00
abstract:BACKGROUND:Larval developmental patterns are extremely varied both between and within phyla, however the genetic mechanisms leading to this diversification are poorly understood. We assembled and compared the developmental transcriptomes for two sea biscuit species (Echinodermata: Echinoidea) with differing patterns of...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4768-9
更新日期:2018-05-18 00:00:00
abstract:BACKGROUND:Leaf blight caused by Calonectria spp. is one of the most destructive diseases to affect Eucalyptus nurseries and plantations. These pathogens mainly attack Eucalyptus, a tree with a diversity of secondary metabolites employed as defense-related phytoalexins. To unravel the fungal adaptive mechanisms to vari...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4739-1
更新日期:2018-05-10 00:00:00
abstract:BACKGROUND:Deep-sea hydrothermal vents are unique chemoautotrophic ecosystems with harsh conditions. Alvinocaris longirostris is one of the dominant crustacean species inhabiting in these extreme environments. It is significant to clarify mechanisms in their adaptation to the vents. Lysine acetylation has been known to...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4745-3
更新日期:2018-05-10 00:00:00
abstract:BACKGROUND:Precise identification of three-dimensional genome organization, especially enhancer-promoter interactions (EPIs), is important to deciphering gene regulation, cell differentiation and disease mechanisms. Currently, it is a challenging task to distinguish true interactions from other nearby non-interacting o...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4459-6
更新日期:2018-05-09 00:00:00
abstract:BACKGROUND:Transcription factors (TFs) play essential roles during plant development and response to environmental stresses. However, the relationships among transcription factors, cis-acting elements and target gene expression under endo- and exogenous stimuli have not been systematically characterized. RESULTS:Here,...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4469-4
更新日期:2018-05-09 00:00:00
abstract:BACKGROUND:The importance of transposable elements (TEs) in the genomic remodeling and chromosomal rearrangements that accompany lineage diversification in vertebrates remains the subject of debate. The major impediment to understanding the roles of TEs in genome evolution is the lack of comparative and integrative ana...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4714-x
更新日期:2018-05-09 00:00:00
abstract:BACKGROUND:Midgut invasion, a major bottleneck for malaria parasites transmission is considered as a potential target for vector-parasite interaction studies. New intervention strategies are required to explore the midgut proteins and their potential role in refractoriness for malaria control in Anopheles mosquitoes. T...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4729-3
更新日期:2018-05-08 00:00:00
abstract:BACKGROUND:In contrast to unidirectional promoters wherein antisense transcription results in short transcripts which are rapidly degraded, bidirectional promoters produce mature transcripts in both sense and antisense orientation. To understand the molecular mechanism of how productive bidirectional transcription is r...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4697-7
更新日期:2018-05-02 00:00:00
abstract:BACKGROUND:The accurate determination of the genomic coordinates for a given gene - its gene model - is of vital importance to the utility of its annotation, and the accuracy of bioinformatic analyses derived from it. Currently-available methods of computational gene prediction, while on the whole successful, frequentl...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4704-z
更新日期:2018-04-27 00:00:00
abstract:BACKGROUND:Pyrenophora tritici-repentis (Ptr) is a necrotrophic fungal pathogen that causes the major wheat disease, tan spot. We set out to provide essential genomics-based resources in order to better understand the pathogenicity mechanisms of this important pathogen. RESULTS:Here, we present eight new Ptr isolate g...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4680-3
更新日期:2018-04-23 00:00:00
abstract:BACKGROUND:Guayule (Parthenium argentatum A. Gray) is a rubber-producing desert shrub native to Mexico and the United States. Guayule represents an alternative to Hevea brasiliensis as a source for commercial natural rubber. The efficient application of modern molecular/genetic tools to guayule improvement requires cha...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4653-6
更新日期:2018-04-19 00:00:00
abstract:BACKGROUND:Most published genome sequences are drafts, and most are dominated by computational gene prediction. Draft genomes typically incorporate considerable sequence data that are not assigned to chromosomes, and predicted genes without quality confidence measures. The current Actinidia chinensis (kiwifruit) 'Hongy...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4656-3
更新日期:2018-04-16 00:00:00
abstract:BACKGROUND:Bread wheat has a large complex genome that makes whole genome resequencing costly. Therefore, genome complexity reduction techniques such as sequence capture make re-sequencing cost effective. With a high-quality draft wheat genome now available it is possible to design capture probe sets and to use them to...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4640-y
更新日期:2018-04-13 00:00:00
abstract::ᅟ: Upon publication of the original article [1], the authors had flagged that there was an error in Fig. 1c, as the key in this figure was displaying incorrectly. The colours had not displayed in the key in the final published article, and instead appear as plain white. ...
journal_title:BMC genomics
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12864-018-4614-0
更新日期:2018-04-11 00:00:00